Co-microencapsulation of Ruellia tuberosa L. and Cosmos caudatus K. Extracts for Pharmaceutical Applications

This study aims to co-microencapsulate the Ruellia tuberosa L. and Cosmos caudatus K. extracts, with chitosan–sodium tripolyphosphate (Na-TPP) as coating material. α-Amylase inhibition antioxidant assays were conducted determine potential of microcapsules used antidiabetic agents. The manufactured under influences pH, Na-TPP concentration, stirring time. optimum microencapsulation conditions selected based on highest encapsulation efficiency. a pH 4, concentration 0.15% (w/v), time 60 min. exhibited an IC50 (inhibitory concentration) value 223.64 ± 0.81 µg/mL α-amylase activity 104.05 0.88 µg/mL. test for release bioactive compounds from was in HCl 1.2 phosphate buffer 7.4 30–120 Results showed that 5.99% 58.96% released at 7.4, respectively, 120 Fourier transform infrared spectra P=O functional group vibrations 1,213.71 cm−1 C–N stretching chitosan 1,155.23 cm−1. Characterization scanning electron microscopy particle size analysis indicated spherical had mean diameter 132.08 µm. current demonstrated co-microencapsulation is promising multifaceted approach enhancement pharmaceutical applications plant extract combinations